Cell Penetrating SdAb Discovery Service

In terms of our Super™ transbody development platform and professional experience of cell penetrating sdAb discovery, Creative Biolabs has established one-stop solutions to generate a series of novel cell penetrating sdAb to meet the growing demand for either research, diagnostic or therapeutic applications.

Cell Penetrating Single Domain Antibody

Single domain antibody (sdAb), also known as V_HH or V_NAR, is the smallest naturally antigen-binding antibody fragments consisting of a single variable antibody domain. These sdAbs with a molecular weight of 12-15 kDa, are discovered in camelids (camels, llamas, and alpacas) and cartilaginous fishes (e.g. sharks), and exhibit specificities and affinities comparable to that of conventional antibodies.

Based on our Super™ transbody development platform and high-throughput screening methods, Creative Biolabs can discover novel sdAbs with high specificity and affinity against any target of interest, especially those that could penetrate the cell while also being capable of specifically binding to the intracellular target proteins for therapeutic discovery. Specifically, a target protein may be an intracellular receptor within a target cell (any mammalian cell, including but not limited to cancer cells, immune system cells, and any other mammalian cells of interest). This strategy widely extends the scope of protein therapeutics and basic research tools and does not dramatically alter the utility and function of sdAbs, such as specificity, high stability, and target affinity.

Advantages of Cell Penetrating sdAb

• Smallest antibody fragment with only ~15 kDa
• Recognize hidden/cleft epitopes that conventional antibodies cannot
• Capabilities of extreme refolding and high stability to function
• Easily clone without being concerned with the disruption of VH/VL pairing
• Outstanding penetrability which can cross the different types of cells
• Short plasma half-life and superior clearance as a diagnostic tool
• Excellent chaperone for the crystallization of challenging targets
• Expressible in both eukaryotic and prokaryotic systems
• Great potential in downstream engineering (e.g. fused to reporter proteins, conjugation, and humanization)

Cell Penetrating sdAb Discovery at Creative Biolabs

Creative Biolabs is dedicated to providing versatile strategies to generate the desired sdAbs, including the construction of high-quality sdAb libraries, the optimal screening strategy, and potential sdAb validation. For maximizing the best properties and advantages of our cell penetrating sdAb, our scientists are pleased to tailor the most appropriate system and optimization of almost every parameter to meet our customer’s specific demands.

Typical Features of Cell Penetrating sdAb Discovery Service

• High-quality novel cell penetrating sdAb development
• Advanced Super™ transbody development platform for optimizing every parameter
• Fully customizable design to meet specific demands
• Optimized downstream engineering procedures
• Comprehensive procedures and experimental details
• Experienced professional team
• Fast turnaround time
• Reliable progress report with timely update
• Affordable price with the best quality

With over years of extensive experience in sdAb development and advanced Super™ transbody development platform, Creative Biolabs can develop novel cell penetrating sdAb to meet our customers’ various project requirements and objectives, from the target identification to the final sdAb production. If you are interested in our cell penetrating sdAb discovery service, please do not hesitate to inquire us to learn more details.

All of our antibody products and services can only be used for preclinical research studies. Do not use them on humans.