IntraMab Discovery Services

Creative Biolabs provides a series of the first-rate IntraMabs with numerous sophisticated modifications and optimization according to researcher’s requirements. Our Super™ Intrabody Development Platform has been studying, accumulating, designing and developing the most advanced technologies for decades in antibody production.

Typical Features of IntraMab

At Creative Biolabs, our IntraMabs are belonging to antibody scaffolds (IgG derived intrabodies), which are small antibody-based formats derived from preexisting mAbs, and manifest stronger thermal stability, more solubility in physiological body fluids, powerful antigenic specificity, and less cost than conventional mAbs for chemically synthesized or manufactured using nonmammalian expression systems. Among these formats, the scFvs and singular IgG V_H and V_L have the most clinical progress as treatments for infectious diseases, a variety of cancers and several chronic inflammatory diseases. As a part of Ab, this intrabody format has the following properties:

• Powerful antigenic specificity than a regular Ab
• Stronger thermal stability and more solubility in physiological body fluids, which power this format with effective therapeutic potentials
• Less cost than conventional mAbs
• Bulk production in bacteria or other expression systems due to the small size

Current multiple pharmaceutical and research applications

Since the IgG derived intrabody was developed, it has been creatively applied in multiple pharmaceutical areas (Alzheimer’s disease, cancer, acute coronary syndrome, etc.) and research fields (novel cell imaging, deep tissue imaging, intracellular blocking, etc.) owing to its small size, simple production, high affinity, and other prominent advantages.

Figure 1 IgG derived V_H and V_L.

Cell-Penetrating Intrabody Discovery Service

Creative Biolabs has established a professional, experienced, and dedicated team to help our clients get direct internalizing intrabody, which has a large potential in the research of targeted therapeutic areas, especially for tumor-related researches.

One-stop IntraMab development service at Creative Biolabs

Creative Biolabs provides versatile strategies to generate the desired IgG derived intrabody:

• Engineer from preexisting mAbs
• Split the dimeric variable domains from common IgG into monomers
• Engineer desired modifications for accurate subcellular localization or endowing it with more customized characteristics

Based on the varied properties and advantages illustrated above, Creative Biolabs is pleased to introduce the most appropriate strategies to discover and develop the IntraMab, which including but not limited to phage display, bacterial two-hybrid system or yeast two-hybrid system. Our scientists can also flexible enough to tailor specific protocol or optimization to meet our clients’ special requirements. Possessing our diligent dedication to constructing high-quality libraries via the most advanced technique, the platforms at Creative Biolabs are unceasingly performing the conventional and advanced screening procedures, and detecting every single potential IgG derived intrabody. Eventually, our customers will acquire the first-rate products and services to conquer more scientific puzzles.

If you are interested in owning the novel IntraMab to promote your research, please do not hesitate to inquire us for more details.

All of our antibody products and services can only be used for preclinical research studies. Do not use them on humans.