Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsOver the years, vigorous research efforts and advances in peptide and protein synthesis, modification, and analysis have led us to believe that an understanding of the protein folding lies within reach. The goal of creating new proteins with tailored structural and functional attributes is just around the corner. Creative Biolabs is dedicated to establishing the most exquisite service platform for our clients and our one-stop protein engineering services can provide comprehensive technical support to advance our clients' projects.
Although the entropic cost of folding a single chain is less than that required for the intermolecular association of modules, the cost of forming a unique three-dimensional structure from an unconstrained linear chain is still substantial. The unfavorable conformational entropy change associated with folding into a unique structure can be decreased by preorganizing the desired structure. Scientists have employed this strategy by using covalent cross-links, synthetic templates, or ligand binding.
Linking peptides to a synthetic template is a non-natural but effective way to covalently constrain peptides to adopt a particular structure. This approach requires artificial templates suitable for the formation of template-assembled synthetic proteins (TASPs). The template is a short oligopeptide designed to form two antiparallel β-strands, stabilized by a disulfide bond at the open end. The ε-amino groups of four lysine side chains located on the template serve as attachment sites for four units of secondary structure. Finally, various TASPs with different stoichiometries and secondary structures were constructed. In such a design, the template can also be a synthetic template. A porphyrin ring to attach four copies of an amphiphilic peptide has been used as a template. The resulting four-helix bundle heme protein (called Helichrome) is as stable as many natural proteins and also possessed a low level of enzymatic activity. In addition, the introduction of ligand binding sites into secondary structural units can also be used to drive assembly into globular protein structures.
Fig.1 Template-directed protein preorganization.
The de novo design and preorganized structures synthesis of proteins play an important role in creating proteins with new functions. Therefore, we can provide various knowledge-based preorganized structures design services, including covalent cross-links, synthetic templates, or ligand binding, to meet customers' specific requirements.
Creative Biolabs has been involved in the field of protein engineering for many years and we are committed to completing your project with high quality. We have accumulated a wealth of scientific experience from our completed projects and provide you with the best services to ensure your requirements are met. If you are interested in our services, please contact us for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
