Function-Guided Therapeutic Protein Design

Therapeutic proteins continue to provide revolutionary new therapies for more and more human diseases, but the development of these powerful drugs needs to address a series of unique challenges. For example, in the early stages of the drug development process, it is best to mitigate potential anti-therapeutic immune responses by molecular recognition of therapeutic protein-peptide fragments. At present, Creative Biolabs has invested a lot of manpower and resources in the field of protein computational design and is committed to continuously developing sequences that can help molecular simulation to predict new and improved functions, and providing valuable services for the application of protein engineering and biomedical research.

Function-Guided Therapeutic Protein Design

Proteins orchestrate a life. Therefore, from multiple perspectives, the ability to design functional proteins in a targeted way will have a tremendous impact on biomedical research and therapeutic development. Computational protein design (CPD) offers the potential to meet this powerful engineering requirement. The aim of this design is to create/design a new molecule that can interfere with disease status by combining appropriate targets or by influencing chemical pathways.

Protein design based on the CPD technology refers to the alteration of amino acid alignment to produce a completely novel protein (design sequence and 3D structure) or to fit predefined structural templates (design sequence only). The most common method used in the rational design is to modify pre-existing proteins locally or to fit amino acid sequences onto a given protein fold. The use of templates avoids the difficulty of predicting unknown sequence folding. As folding remains unchanged, skeleton atoms are placed directly on the framework. The most stable side chains are then added to the skeleton to produce functional proteins.

Fig.1 An overview of the methods of therapeutic protein design. (Roy, 2017)

Services

With the improvement of computing power and algorithm, the computer design of biotherapeutics is a promising strategy to solve the challenges of therapeutic protein design, for example, find the best delivery mode of designed biotherapeutic drugs, predict and minimize miss-target effect, predict and optimize the absorption, distribution, metabolism and excretion (ADME) of designed biotherapeutic drugs. Thanks to our continuous accumulation and progress in protein engineering and therapeutic protein design, our computer design platform integrates protein design based on structure and function, protein de-immunization based on sequence, and cutting-edge algorithms for finding design space. It can provide guidance for researchers to develop the most promising therapeutic protein candidate drugs.

Our function-guided therapeutic protein design services include:

In silico-based Enzyme Binding Site Analysis	Therapeutic Protein Fold Recognition
Therapeutic Protein Structure Assessment	RNA Systems Molecular Dynamics Simulations
Protein-Protein Interactions Analysis of Therapeutic Biomolecules	Ion Channels Modeling Service
Functional Motions Analysis of Therapeutic Biomolecules	Knowledge-based Protein Design
B Cell Epitopes Prediction Service	T Cell Epitopes Prediction Service

With the progress of our understanding of protein function, the predictive ability of rational design of therapeutic proteins is expected to be enhanced by combining function-guided protein design with immunoinformatic predictors. Creative Biolabs is looking forward to providing a credible design that is better and worthy of experimentation for the beginning of your protein engineering project practice, reducing input costs and saving time. If you want to know more information about our services, please contact us.

Reference

Roy, A.; et al. In silico methods for design of biological therapeutics. Methods. 2017, 131: 33-65.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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