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Magic™ Antibody Discovery - Cynomolgus LILRB4 / CD85k / ILT3 (22-259) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP0582F)

Datasheet
This membrane protein is Cynomolgus LILRB4 / CD85k / ILT3 (22-259). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Cynomolgus
  • Target Protein
  • LILRB4 / CD85k / ILT3
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 52.7 kDa. As a result of glycosylation, the protein migrates as 60-66 kDa under reducing (R) condition, and 120-140 kDa under non-reducing (NR) condition (SDS-PAGE).
  • Sequence
  • AA Gln 22 - Glu 259 (Accession # XP_015297198.1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >85% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • LILRB4 / CD85k / ILT3
  • Full Name
  • leukocyte immunoglobulin like receptor B4
  • Introduction
  • This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • LILRB4, ILT3, LIR5, CD85K, HM18

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