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Magic™ Antibody Discovery - Human 4-1BB Ligand / TNFSF9 (71-254) Membrane Protein, Partial, His- -Flag- tag (CAT#: MP0907F)

Datasheet
This membrane protein is Human 4-1BB Ligand / TNFSF9 (24-186). It has been tested in SDS-PAGE, SEC-SEC-MALS, ELISA, BLI. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • 4-1BB Ligand / TNFSF9
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 62.8 kDa. The protein migrates as 55-60 kDa under non-reducing (NR) condition (SDS-PAGE).
  • Sequence
  • AA Arg 71 - Glu 254 (Accession # P41273-1) .

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, SEC-SEC-MALS, ELISA, BLI
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the N-terminus, followed by a flag tag.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • 4-1BB Ligand / TNFSF9
  • Full Name
  • TNF superfamily member 9
  • Introduction
  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
  • Alternative Names
  • CD137L; TNLG5A; 4-1BB-L; tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL; homolog of mouse 4-1BB-L; receptor 4-1BB ligand; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5A; tumor necrosis factor superfamily member 9

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