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Magic™ Antibody Discovery - Human BAFFR / TNFRSF13C (7-71) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP0963F)

Datasheet
This membrane protein is Human BAFFR / TNFRSF13C (7-71). It has been tested in SDS-PAGE, ELISA, SPR. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • BAFFR / TNFRSF13C
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 33.2 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Ser 7 - Ala 71 (Accession # Q96RJ3-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, SPR
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • BAFFR / TNFRSF13C
  • Full Name
  • TNF receptor superfamily member 13C
  • Introduction
  • B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
  • Alternative Names
  • BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin; tumor necrosis factor receptor superfamily member 13C; B cell-activating factor receptor; BAFF receptor; BLyS receptor 3

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