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Magic™ Antibody Discovery - Mouse gp130 / CD130 / IL-6 R beta (23-617) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP0170F)

Datasheet
This membrane protein is Mouse gp130 / CD130 / IL-6 R beta (23-617). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Mouse
  • Target Protein
  • gp130 / CD130 / IL-6 R beta
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 93.3 kDa. The protein migrates as 120-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Gln 23 - Glu 617 (Accession # NP_034690).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • gp130 / CD130 / IL-6 R beta
  • Full Name
  • interleukin 6 signal transducer
  • Introduction
  • The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.
  • Alternative Names
  • gp13; CD130; gp130; AA389424; BB405851; D13Ertd699; D13Ertd699e; 5133400A03Rik; interleukin-6 receptor subunit beta; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; membrane glycoprotein 130; oncostatin-M receptor subunit alpha

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