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Magic™ Antibody Discovery - Human Complement Factor D / CFD (26-253) Membrane Protein, Partial, -His tag (CAT#: MP1333F)

Datasheet
This membrane protein is Human Complement Factor D / CFD (26-253). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Complement Factor D / CFD
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 26.3 kDa. The protein migrates as 28 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Ile 26 - Ala 253 (Accession # P00746-1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH8.0. Normally glycerol is added as protectant before lyophilizatio

Target

  • Target Protein
  • Complement Factor D / CFD
  • Full Name
  • complement factor D
  • Introduction
  • This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease
  • Alternative Names
  • DF; ADN; PFD; ADIPSIN; complement factor D; C3 convertase activator; D component of complement (adipsin); complement factor D preproprotein; properdin factor D

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