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Magic™ Antibody Discovery - Mouse ADAM17 / TACE / CD156b (18-563) Membrane Protein, Partial, -His tag (CAT#: MP0922F)

Datasheet
This membrane protein is Mouse ADAM17 / TACE / CD156b (19-137). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Mouse
  • Target Protein
  • ADAM17 / TACE / CD156b
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 63.4 kDa. The protein migrates as 19 kDa and 20 kDa (Propeptide), 55-66 kDa (Mature-ADAM17) and 75-94 kDa (Pro-ADAM17) under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Pro 18 - Asp 563 (Accession # Q9Z0F8).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >85% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM MES, 150 mM NaCl, pH6.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • ADAM17 / TACE / CD156b
  • Full Name
  • a disintegrin and metallopeptidase domain 17
  • Introduction
  • This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero or fail to survive beyond one week of age. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing.
  • Alternative Names
  • Tac; Tace; CD156b; disintegrin and metalloproteinase domain-containing protein 17; TNF-alpha convertase; TNF-alpha converting enzyme

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