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Magic™ Antibody Discovery - Human Serpin D1 / Heparin Cofactor II (20-499) Membrane Protein, Partial, -His tag (CAT#: MP0406F)

Datasheet
This membrane protein is Human Serpin D1 / Heparin Cofactor II (20-499). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Serpin D1 / Heparin Cofactor II
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 55.7 kDa. The protein migrates as 65-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Gly 20 - Ser 499 (Accession # AAH35028).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH 7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Serpin D1 / Heparin Cofactor II
  • Full Name
  • serpin family D member 1
  • Introduction
  • This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency.
  • Alternative Names
  • HC2; LS2; HCF2; HCII; HLS2; THPH10; D22S673; heparin cofactor 2; heparin cofactor II splice isoform; leuserpin 2; protease inhibitor leuserpin-2; serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1; serpin D1; serpin peptidase inhibitor, clade D (heparin cofactor), member 1

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