Close
Close

Magic™ Antibody Discovery - Rabbit LDL R (9-765) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP0610F)

Datasheet
This membrane protein is Rabbit LDL R (9-765). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Rabbit
  • Target Protein
  • LDL R
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 109.2 kDa. The protein migrates as 120-140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Ala 9 - Gly 765 (Accession # P20063-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • LDL R
  • Full Name
  • low density lipoprotein receptor
  • Introduction
  • The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
  • Alternative Names
  • LDLR, FH, FHC, LDLCQ2

Customer reviews and Q&As    

Related Products
Online Inquiry
CONTACT US
USA:
Europe:
Germany:
Call us at:
USA:
UK:
Germany:
Fax:
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us
© 2024 Creative Biolabs. | Contact Us