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Magic™ Antibody Discovery - Human IGF-I R / CD221 (31-932) Membrane Protein, Partial, -His tag (CAT#: MP0246F)

Datasheet
This membrane protein is Human IGF-I R / CD221 (31-932). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • IGF-I R / CD221
  • Protein Length
  • ECD
  • Molecular Weight
  • This protein contains a furin convertase cleavage site, 737-RKRR-740, and will be partially processed into N (α chain) and C-terminal fragment (partial β chain) with calculated MW of 81.0 kDa and 23.8 kDa respectively. The protein migrates as 36 kDa (partial β chain), 96-116 kDa (α chain) and 120-140 kDa (α chain & partial β chain) due to glycosylation.
  • Sequence
  • AA Glu 31 - Asn 932 (Accession # P08069-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • IGF-I R / CD221
  • Full Name
  • insulin like growth factor 1 receptor
  • Introduction
  • This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
  • Alternative Names
  • IGFR; CD221; IGFIR; JTK13; insulin-like growth factor 1 receptor; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2

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