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Magic™ Membrane Protein Human ACKR4 (Atypical chemokine receptor 4) expressed in E.coli for Antibody Discovery (CAT#: MP1325J)

Datasheet
This product is a 39 kDa Human ACKR4 membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ACKR4
  • Protein Length
  • Full-length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 39 kDa
  • TMD
  • 7
  • Sequence
  • MALEQNQSTDYYYEENEMNGTYDYSQYELICIKEDVREFAKVFLPVFLTIVFVIGLAGNS MVVAIYAYYKKQRTKTDVYILNLAVADLLLLFTLPFWAVNAVHGWVLGKIMCKITSALYT LNFVSGMQFLACISIDRYVAVTKVPSQSGVGKPCWIICFCVWMAAILLSIPQLVFYTVND NARCIPIFPRYLGTSMKALIQMLEICIGFVVPFLIMGVCYFITARTLMKMPNIKISRPLK VLLTVVIVFIVTQLPYNIVKFCRAIDIIYSLITSCNMSKRMDIAIQVTESIALFHSCLNP ILYVFMGASFKNYVMKVAKKYGSWRRQRQSVEEFPFDSEGPTEPTSTFSI

Product Description

  • Expression Systems
  • E.coli
  • Tag
  • N-His or Tag-Free
  • Reconstitution
  • Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration).
  • Purity
  • >85% as determined by SDS-PAGE
  • Buffer
  • Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Target

  • Target Protein
  • ACKR4
  • Full Name
  • Atypical chemokine receptor 4
  • Introduction
  • Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.
  • Alternative Names
  • ACKR4; Atypical chemokine receptor 4; C C chemokine receptor type 11; C-C chemokine receptor type 11; C-C CKR-11; CC chemokine receptor like 1; CC chemokine receptor-like 1; CC CKR 11; CC-CKR-11; CCBP2; CCCKR11; CCR 11; CCR-11; CCR10; CCRL1; CCRL1_HUMAN; CCX CKR; Chemocentryx chemokine receptor; Chemokine (C C motif) receptor like 1; Chemokine cc motif receptor like protein 1; Chemokine receptor like 1; CKR11; CKRB; Orphan seven transmembrane receptor chemokine related; PPR1; VSHK1

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