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Magic™ Membrane Protein Human ATP6V0A4 (ATPase H+ transporting V0 subunit a4) Full Length (CAT#: MPC0414K) Made to Order

Datasheet
This product is a 96.3 kDa Human ATP6V0A4 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ATP6V0A4
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion Transporter
  • Molecular Weight
  • 96.3 kDa
  • TMD
  • 8
  • Sequence
  • MVSVFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRK
    FVNEVRRCESLERILRFLEDEMQNEIVVQLLEKSPLTPLPREMITLETVL
    EKLEGELQEANQNQQALKQSFLELTELKYLLKKTQDFFETETNLADDFFT
    EDTSGLLELKAVPAYMTGKLGFIAGVINRERMASFERLLWRICRGNVYLK
    FSEMDAPLEDPVTKEEIQKNIFIIFYQGEQLRQKIKKICDGFRATVYPCP
    EPAVERREMLESVNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQ
    KMKAVYHILNMCNIDVTQQCVIAEIWFPVADATRIKRALEQGMELSGSSM
    APIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIIT
    FPFLFAVMFGDCGHGTVMLLAALWMILNERRLLSQKTDNEIWNTFFHGRY
    LILLMGIFSIYTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWNTHVMEES
    LYLQLDPAIPGVYFGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIV
    QMVFGVILSLFNHIYFRRTLNIILQFIPEMIFILCLFGYLVFMIIFKWCC
    FDVHVSQHAPSILIHFINMFLFNYSDSSNAPLYKHQQEVQSFFVVMALIS
    VPWMLLIKPFILRASHRKSQLQASRIQEDATENIEGDSSSPSSRSGQRTS
    ADTHGALDDHGEEFNFGDVFVHQAIHTIEYCLGCISNTASYLRLWALSLA
    HAQLSEVLWTMVMNSGLQTRGWGGIVGVFIIFAVFAVLTVAILLIMEGLS
    AFLHALRLHWVEFQNKFYVGDGYKFSPFSFKHILDGTAEE

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • ATP6V0A4
  • Full Name
  • ATPase H+ transporting V0 subunit a4
  • Introduction
  • This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.
  • Alternative Names
  • A4; STV1; VPH1; VPP2; DRTA3; RTA1C; RTADR; ATP6N2; RDRTA2; ATP6N1B; V-type proton ATPase 116 kDa subunit a isoform 4; V-type proton ATPase 116 kDa subunit a; ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1B; ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kD); ATPase, H+ transporting, lysosomal V0 subunit a4; H(+)-transporting two-sector ATPase, noncatalytic accessory protein 1B; V-ATPase 116 kDa; vacuolar proton pump 116 kDa accessory subunit; vacuolar proton pump, subunit 2; ATP6V0A4; ATPase H+ transporting V0 subunit a4

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