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Magic™ Membrane Protein Human BMPR1B (Bone morphogenetic protein receptor type 1B) Expressed in NS0 for Antibody Discovery, Partial (14-126aa) (CAT#: MPX0221K)

Datasheet
This product is a 40 kDa Human BMPR1B membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • BMPR1B
  • Protein Length
  • Partial (14-126aa)
  • Protein Class
  • Transferase
  • Molecular Weight
  • 40 kDa
  • TMD
  • 1
  • Sequence
  • KKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTD
    GYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERN
    ECNKDLHPTLPPLKNRDFVDGPIHHR

Product Description

  • Expression Systems
  • NS0
  • Tag
  • hIgG1 Fc and 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <1.0 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • BMPR1B
  • Full Name
  • Bone morphogenetic protein receptor type 1B
  • Introduction
  • This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene.
  • Alternative Names
  • BMPR1B; ALK6; AMDD; BDA2; ALK-6; BDA1D; CDw293; bone morphogenetic protein receptor type-1B; BMP type-1B receptor; BMPR-1B; activin receptor-like kinase 6; bone morphogenetic protein receptor, type IB; serine/threonine receptor kinase; Bone morphogenetic protein receptor type 1B

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