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Magic™ Membrane Protein Human CDH12 (Cadherin 12) Expressed in NS0 for Antibody Discovery, Partial (24-609aa) (CAT#: MPX0414K)

Datasheet
This product is a 92.5 kDa Human CDH12 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CDH12
  • Protein Length
  • Partial (24-609aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 92.5 kDa
  • TMD
  • 1
  • Sequence
  • QPQPQQTLATEPRENVIHLPGQRSHFQ
    RVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGT
    VFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKV
    QDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVY
    SILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLA
    GTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQ
    NAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEA
    SNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVG
    TIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRE
    STAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCEN
    AKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGI
    ETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILS
    CNVEAIFLP

Product Description

  • Activity
  • Yes
  • Expression Systems
  • NS0
  • Tag
  • hIgG1 Fc and 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in Tris-Citrate, NaCl and CaCl2.

Target

  • Target Protein
  • CDH12
  • Full Name
  • Cadherin 12
  • Introduction
  • This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
  • Alternative Names
  • CDH12; CDHB; cadherin-12; Br-cadherin; N-cadherin 2; brain-cadherin; cadherin, neural type, 2; neural type cadherin 2; neuronal cadherin 2; Cadherin 12

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