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Magic™ Membrane Protein Human COX10 (Cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10) Full Length (CAT#: MPC1340K) Made to Order

Datasheet
This product is a 48.9 kDa Human COX10 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • COX10
  • Protein Length
  • Full length
  • Protein Class
  • Transferase
  • Molecular Weight
  • 48.9 kDa
  • TMD
  • 7
  • Sequence
  • MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITF
    QHFSFLKRMYVTQLNRSHNQQVRPKPEPVASPFLEKTSSGQAKAEIYEMR
    PLSPPSLSLSRKPNEKELIELEPDSVIEDSIDVGKETKEEKRWKEMKLQV
    YDLPGILARLSKIKLTALVVSTTAAGFALAPGPFDWPCFLLTSVGTGLAS
    CAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAI
    LTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGW
    TAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHP
    GLCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFY
    VDADRRSSRRLFFCSLWHLPLLLLLMLTCKRPSGGGDAGPPPS

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • COX10
  • Full Name
  • Cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
  • Introduction
  • Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.
  • Alternative Names
  • COX10; MC4DN3; protoheme IX farnesyltransferase, mitochondrial; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase; COX10, heme A:farnesyltransferase; cytochrome c oxidase assembly factor; cytochrome c oxidase assembly homolog 10; cytochrome c oxidase assembly protein; cytochrome c oxidase subunit X; heme A: farnesyltransferase; heme O synthase; Cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10

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