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Magic™ Membrane Protein Human DUOX1 (Dual oxidase 1) Full Length (CAT#: MPC2968K) Made to Order

Datasheet
This product is a made-to-order Human DUOX1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • DUOX1
  • Protein Length
  • Full length
  • Protein Class
  • Oxidoreductase
  • TMD
  • 7
  • Sequence
  • MGFCLALAWTLLVGAWTPLGAQNPISWEVQRFDGWYNNLMEHRWGSKGSR
    LQRLVPASYADGVYQPLGEPHLPNPRDLSNTISRGPAGLASLRNRTVLGV
    FFGYHVLSDLVSVETPGCPAEFLNIRIPPGDPMFDPDQRGDVVLPFQRSR
    WDPETGRSPSNPRDPANQVTGWLDGSAIYGSSHSWSDALRSFSRGQLASG
    PDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGL
    LWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL
    QKTLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGV
    INRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVL
    VEDVRDFWPGPLKFSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRW
    QDINPALSRSNDTVLEATAALYNQDLSWLELLPGGLLESHRDPGPLFSTI
    VLEQFVRLRDGDRYWFENTRNGLFSKKEIEEIRNTTLQDVLVAVINIDPS
    ALQPNVFVWHKGDPCPQPRQLSTEGLPACAPSVVRDYFEGSGFGFGVTIG
    TLCCFPLVSLLSAWIVARLRMRNFKRLQGQDRQSIVSEKLVGGMEALEWQ
    GHKEPCRPVLVYLQPGQIRVVDGRLTVLRTIQLQPPQKVNFVLSSNRGRR
    TLLLKIPKEYDLVLLFNLEEERQALVENLRGALKESGLSIQEWELREQEL
    MRAAVTREQRRHLLETFFRHLFSQVLDINQADAGTLPLDSSQKVREALTC
    ELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKG
    SPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVV
    ESMFRESGFQDKEELTWEDFHFMLRDHNSELRFTQLCVKGVEVPEVIKDL
    CRRASYISQDMICPSPRVSARCSRSDIETELTPQRLQCPMDTDPPQEIRR
    RFGKKVTSFQPLLFTEAHREKFQRSCLHQTVQQFKRFIENYRRHIGCVAV
    FYAIAGGLFLERAYYYAFAAHHTGITDTTRVGIILSRGTAASISFMFSYI
    LLTMCRNLITFLRETFLNRYVPFDAAVDFHRLIASTAIVLTVLHSVGHVV
    NVYLFSISPLSVLSCLFPGLFHDDGSELPQKYYWWFFQTVPGLTGVVLLL
    ILAIMYVFASHHFRRRSFRGFWLTHHLYILLYVLLIIHGSFALIQLPRFH
    IFFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEY
    KSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIY
    SAPTGDRCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILK
    DLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDHQDLVSV
    HIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEP
    FFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYEN
    F

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • DUOX1
  • Full Name
  • Dual oxidase 1
  • Introduction
  • The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
  • Alternative Names
  • DUOX1; LNOX1; THOX1; NOXEF1; NADPH thyroid oxidase 1; flavoprotein NADPH oxidase; large NOX 1; long NOX 1; nicotinamide adenine dinucleotide phosphate oxidase; thyroid oxidase 1; Dual oxidase 1

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