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Magic™ Membrane Protein Human GP5 (Glycoprotein V platelet) Expressed in NS0 for Antibody Discovery, Partial (17-523aa) (CAT#: MPX0742K)

Datasheet
This product is a 56 kDa Human GP5 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GP5
  • Protein Length
  • Partial (17-523aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 56 kDa
  • TMD
  • 1
  • Sequence
  • QPFPCPPACKCVFRDAAQCSGGDVARISALGLPT
    NLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKL
    KTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQE
    LALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLL
    LHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLS
    RNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRT
    QLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNG
    LTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLE
    TLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPR
    CAGPGAHAGLPLWALPGGDAECPGPRGPPPRPAADSSSEAPVHPALAPNS
    SEPWVWAQPVTTGKGQDHSPFWG

Product Description

  • Activity
  • Yes
  • Expression Systems
  • NS0
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 500 μg/mL in PBS.
  • Endotoxin
  • <1.0 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • GP5
  • Full Name
  • Glycoprotein V platelet
  • Introduction
  • Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder.
  • Alternative Names
  • GP5; GPV; CD42d; platelet glycoprotein V; glycoprotein 5; Glycoprotein V platelet

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