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Magic™ Membrane Protein Human HFE (Homeostatic iron regulator) Full Length (CAT#: MPC1265K) Made to Order

This product is a 40.1 kDa Human HFE membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • HFE
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 40.1 kDa
  • TMD
  • 1
  • Sequence
  • MGPRARPALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEAL
    GYVDDQLFVFYDHESRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTV
    DFWTIMENHNHSKESHTLQVILGCEMQEDNSTEGYWKYGYDGQDHLEFCP
    DTLDWRAAEPRAWPTKLEWERHKIRARQNRAYLERDCPAQLQQLLELGRG
    VLDQQVPPLVKVTHHVTSSVTTLRCRALNYYPQNITMKWLKDKQPMDAKE
    FEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPS
    PSGTLVIGVISGIAVFVVILFIGILFIILRKRQGSRGAMGHYVLAERE

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • HFE
  • Full Name
  • Homeostatic iron regulator
  • Introduction
  • The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.
  • Alternative Names
  • HFE; HH; HFE1; HLA-H; MVCD7; TFQTL2; hereditary hemochromatosis protein; MHC class I-like protein HFE; hereditary hemochromatosis protein HLA-H; high Fe; Homeostatic iron regulator

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