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Magic™ Membrane Protein Human HLA-DRB5 (Major histocompatibility complex, class II, DR beta 5) Expressed in E.coli with 6xHis tag at the N-terminus for Antibody Discovery, Partial (30-227aa) (CAT#: MPX4140K)

Datasheet
This product is a 27.1 kDa Human HLA-DRB5 membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • HLA-DRB5
  • Protein Length
  • Partial (30-227aa)
  • Protein Class
  • Immunity
  • Molecular Weight
  • 27.1 kDa
  • TMD
  • 1
  • Sequence
  • GDTRPRFLQQDKYECHFFNGTERVRFLHRDIYNQEEDLRFDSDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTVQRRVEPKVTVYPARTQTLQHHNLLVCSVNGFYPGSIEVRWFRNSQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRAQSESAQSK

Product Description

  • Expression Systems
  • E.coli
  • Tag
  • 6xHis tag at the N-terminus
  • Protein Format
  • Soluble
  • Purity
  • >90% as determined by SDS-PAGE
  • Buffer
  • Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Target

  • Target Protein
  • HLA-DRB5
  • Full Name
  • Major histocompatibility complex, class II, DR beta 5
  • Introduction
  • HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene.
  • Alternative Names
  • HLA-DRB5; HLA-DRB5*; DR beta-5; HLA class II histocompatibility antigen, DR-5 beta chain; MHC class II antigen DRB5; Major histocompatibility complex, class II, DR beta 5

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