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Magic™ Membrane Protein Human IL12RB2 (Interleukin 12 receptor subunit beta 2) Expressed in NS0 for Antibody Discovery, Partial (24-622aa) (CAT#: MPX0495K)

Datasheet
This product is a 95 kDa Human IL12RB2 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • IL12RB2
  • Protein Length
  • Partial (24-622aa)
  • Protein Class
  • Receptor
  • Molecular Weight
  • 95 kDa
  • TMD
  • 1
  • Sequence
  • KIDACKRGDVTVKPSHVILLGSTVNIT
    CSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFV
    CKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRD
    THLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKV
    TAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQKASVSRCTLYWRDEG
    LVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHL
    YKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISLFWKNLSV
    SEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAA
    NSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSA
    VQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIRVY
    ALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQM
    GCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSLQPRVTYVLWMTA
    LTAAGESSHGNEREFCLQGKAN

Product Description

  • Activity
  • Yes
  • Expression Systems
  • NS0
  • Tag
  • hIgG1 Fc and 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 250 μg/mL in PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.

Target

  • Target Protein
  • IL12RB2
  • Full Name
  • Interleukin 12 receptor subunit beta 2
  • Introduction
  • The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.
  • Alternative Names
  • IL12RB2; interleukin-12 receptor subunit beta-2; IL-12 receptor subunit beta-2; IL-12R subunit beta-2; interleukin 12 receptor, beta 2; interleukin-12 receptor beta-2 chain; Interleukin 12 receptor subunit beta 2

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