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Magic™ Membrane Protein Human KCND2 (Potassium voltage-gated channel subfamily D member 2) Full Length (CAT#: MPC0592K) Made to Order

Datasheet
This product is a 70.5 kDa Human KCND2 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • KCND2
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion channel
  • Molecular Weight
  • 70.5 kDa
  • TMD
  • 6
  • Sequence
  • MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGT
    RFQTWQDTLERYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYR
    TGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQD
    DADTDTAGESALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVI
    ANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAA
    APSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRI
    FKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSS
    ASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIAL
    PVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRN
    GLLSNQLQSSEDEQAFVSKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFE
    ESCMEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKKTFRIPNANVSGSHQ
    GSIQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISI
    PTPPVTTPEGDDRPESPEYSGGNIVRVSAL

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • KCND2
  • Full Name
  • Potassium voltage-gated channel subfamily D member 2
  • Introduction
  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.
  • Alternative Names
  • RK5; KV4.2; potassium voltage-gated channel subfamily D member 2; potassium channel, voltage gated Shal related subfamily D, member 2; voltage-gated potassium channel subunit Kv4.2; voltage-sensitive potassium channel; KCND2; Potassium voltage-gated channel subfamily D member 2

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