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Magic™ Membrane Protein Human LIFR (LIF receptor subunit alpha) Expressed in Baculovirus/Insect expression system for Antibody Discovery, Partial (45-833aa) (CAT#: MPX0598K)

Datasheet
This product is a 89 kDa Human LIFR membrane protein expressed in Baculovirus/Insect expression system. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • LIFR
  • Protein Length
  • Partial (45-833aa)
  • Protein Class
  • Receptor
  • Molecular Weight
  • 89 kDa
  • TMD
  • 1
  • Sequence
  • QKKGAP
    HDLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKI
    PALSHGDYEITINSLHDFGSSTSKFTLNEQNVSLIPDTPEILNLSADFST
    STLYLKWNDRGSVFPHRSNVIWEIKVLRKESMELVKLVTHNTTLNGKDTL
    HHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNISWIPDS
    QTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIK
    IRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEII
    CSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQML
    PNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVK
    LSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLN
    PYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGK
    NLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK
    NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYD
    PNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFF
    LYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVE
    ELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIAD
    LQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENS

Product Description

  • Activity
  • Yes
  • Expression Systems
  • Baculovirus/Insect expression system
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • LIFR
  • Full Name
  • LIF receptor subunit alpha
  • Introduction
  • This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene.
  • Alternative Names
  • LIFR; SWS; SJS2; STWS; CD118; LIF-R; leukemia inhibitory factor receptor; CD118 antigen; LIF receptor alpha; leukemia inhibitory factor receptor alpha; LIF receptor subunit alpha

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