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Magic™ Membrane Protein Human PSENEN (Presenilin enhancer, gamma-secretase subunit) Expressed in vitro E.coli expression system, Full Length (CAT#: MPX1059K)

Datasheet
This product is a Human PSENEN membrane protein expressed in vitro E.coli expression system. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PSENEN
  • Protein Length
  • Full Length
  • Protein Class
  • Receptor
  • Molecular Weight
  • 14.8 kDa
  • TMD
  • 2
  • Sequence
  • MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGTP

Product Description

  • Expression Systems
  • in vitro E.coli expression system
  • Tag
  • 10xHis tag at the N-terminus
  • Protein Format
  • Soluble
  • Purity
  • >85% as determined by SDS-PAGE.
  • Buffer
  • Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Target

  • Target Protein
  • PSENEN
  • Full Name
  • Presenilin enhancer, gamma-secretase subunit
  • Introduction
  • Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • PSENEN; PEN2; PEN-2; MDS033; ACNINV2; MSTP064; gamma-secretase subunit PEN-2; hematopoietic stem/progenitor cells protein MDS033; presenilin enhancer 2 homolog; Presenilin enhancer, gamma-secretase subunit

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