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NativeExtract™ Human CHRM2 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX384)

Datasheet
This product is recombinant Human CHRM2 protein in native nanodisc form. The synthetic compound we developed can solubilize the CHRM2 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CHRM2
  • Protein Length
  • Full length
  • Molecular Weight
  • 51.5 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CHRM2
  • Full Name
  • Cholinergic receptor muscarinic 2
  • Introduction
  • The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.
  • Alternative Names
  • HM2; muscarinic acetylcholine receptor M2; 7TM receptor; acetylcholine receptor, muscarinic 2; muscarinic M2 receptor; CHRM2; Cholinergic receptor muscarinic 2

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