B-Cell Sorting Based sdAb Discovery
Creative Biolabs is a leading service provider that is specialized in sdAb discovery and development. Based on our advanced technology platforms, we have won a good reputation for accomplishing numerous challenging sdAb development projects successfully. Now, our scientists with extensive experience in sdAb generation will leverage the leading B-cell functional antibody discovery technology to develop specific sdAbs.
B-Cell Sorting Platform
B cell sorting technology has evolved rapidly in recent years with its efficiency and feasibility in rapidly obtaining specific sdAbs. Our state-of-the-art Native™ platform, including B cell screening, cloning, and in vitro expression, provides a novel solution for discovering and developing novel sdAb therapies. This platform allows us to delineate antigen-specific sdAb responses at the clonal level for better understanding of the sdAb candidates and this methodology is applicable for isolating/developing essential research reagents and therapeutic sdAbs.
Key Features of B-Cell Sorting Platform
- Cutting edge tech to maximize the chance of finding your desired sdAb
- Ultra-high-throughput screening of B cells for sdAb selection
- Streamlined automated workflow and platform
- High diversity, high specificity reagent sdAbs
- Ideal for important and challenging target cells
- Fast track sdAb discovery to shorten your time and investment
Fig.1 B-cell-sorting-based sdAb discovery.
sdAb Discovery via our B-Cell Sorting Platform
sdAbs are a growing class of therapeutic molecules that have become more essential agents for research, diagnostic and therapeutic areas, and the existing B cell repertoire is a potential source of these sdAbs. Creative Biolabs has established a high-throughput B-cell sorting platform to screen and generate numerous sdAbs from individual, target-specific B cells and discover specific sdAbs in a short-period for our customers all over the world.
Our scientists leverage B-cell sorting technology to offer sdAb discovery service worldwide, involving single B cell isolation, screening, and evaluation via flow cytometry, single B-cell sequence analysis, cloning of single cells, and expression of antibody. Using flow cytometry, it can not only interrogate millions of B-cells from immunized or non-immunized animals but also sort the ones that match the antigen reactivity criteria with the biological activity of interest and favorable manufacturing properties.
Our antigen-specific B cell sorting allows efficient generation of sdAbs with high affinity and discriminative capacity, likely against any desired antigen at the level of individual cells. Moreover, we will ensure the success rate of single B cell sdAb cloning and sequencing, which is critical for single B cell-based sdAb discovery to enable the development of potential optimized sdAb candidates. As each sdAb has precise specificity for a given antigen by B-cell sorting, these sdAbs will be widely used in biological research, clinical diagnosis, and therapy.
Creative Biolabs has made a long-term commitment to the discovery and development of sdAb. To bring our customers impeccable service of sdAb discovery, our seasoned scientific team has developed an integrated B-cell sorting platform to maximize our customers' success in discovering valuable sdAbs. If you have additional questions about our service or would like to consult with the experts, please feel free to contact us.
Case Study
We are offering highly customized CRO services to assist your Single Domain Antibody (sdAb) related projects. Please Contact Us for more details.
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