Generation of Specificity Controllable sdAb
With over a decade of extensive experience in developing novel sdAbs, Creative Biolabs is professional in supporting a variety of sdAb development projects. Our scientists are proud to tailor and conduct the best-fit proposal for the generation of specificity controllable sdAb to meet your particular application requirements.
Introduction of Specificity Controllable sdAb
Recently, a generally applicable sdAb has been generated to specifically control the location and function of its target proteins. The range of applications of sdAbs would be significantly expanded if their binding affinity toward their targets could be controlled with other molecules. The engineered sdAbs can interrogate the roles of fusion proteins in basic biological processes by controlling the cellular localization of fusion proteins. Combination of the high selectivity of sdAbs with the specificity control offered with the engineering of sdAb or other small molecules, these appropriate compound tools can reversibly control the location and function of a large variety of target proteins.
Fig.1 Specificity controllable sdAb.
Generation of Specificity Controllable sdAb
As the starting point for the generation of specificity controllable sdAb, Creative Biolabs can design the controllable sdAb engineering program according to our customer needs. Specificity controllable sdAbs can be generated by the construction of fusion protein and selection of the suitable ligands to control the binding affinities. These complexes of specificity controllable sdAbs and ligands exploit the change in conformation to disrupt or improve the binding of the sdAbs to their targets.
Taken the advantages of deep understanding of sdAb engineering, Creative Biolabs has explored novel solutions through rationally designed engineering processes to obtain the specificity controllable sdAb. The binding affinities of this specificity controllable sdAb can be adjusted in the presence and absence of the ligands. Furthermore, the design concept of specificity controllable sdAbs at Creative Biolabs is applicable to expand to other switchable targets within the availability of structural information on the interaction of sdAbs with their targets. We can rapidly optimize a series of specificity controllable sdAbs to meet your project requirements.
Based on our advanced platforms and robust technologies in the field of sdAb, Creative Biolabs has been long-term devoted to the development of sdAbs to satisfy your particular application requirements. Scientists at Creative Biolabs are confident in offering the generation of specificity controllable sdAb services for our customers all over the world. If you are interested in the development of specific sdAb using in the research, please feel free to contact us for more details.
Case Study
We are offering highly customized CRO services to assist your Single Domain Antibody (sdAb) related projects. Please Contact Us for more details.
Applications
