SLC16A7 Membrane Protein Introduction

Introduction of SLC16A7

Solute carrier family 16 member 7 (SLC16A7), also known as monocarboxylate transporter 2 (MCT2), is encoded by the gene SLC16A7. It is a member of the monocarboxylate transporter family. SLC16A7 is a proton-coupled monocarboxylate transporter, which is mainly found in cells with low monoacid concentration, such as renal tubules, nerve cells, and sperm tail. Among the MCT family, MCT2 (SLC16A7) has the highest affinity for lactic acid. In parallel, SLC16A7 gene transcription has been demonstrated to respond with high-sensitivity to hypoxia, intracellular pH, and, to lactate.

Basic Information of SLC16A7
Protein Name	Monocarboxylate transporter 2
Gene Name	SLC16A7
Aliases	Solute carrier family 16 member 7
Organism	Homo sapiens (Human)
UniProt ID	O60669
Transmembrane Times	12
Length (aa)	478
Sequence	MPPMPSAPPVHPPPDGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNAINYRLLAKERKEENARQKTRESEPLSKSKHSEDVNVKVSNAQSVTSERETNI

Function of SLC16A7 Membrane Protein

The MCT family can promote nutrient absorption, affect metabolic dynamic balance, regulate cell pH and participate in drug delivery. For SLC16A7, it is mainly responsible for the transport of lactic acid and is only expressed in the small intestine. In the process of transporting protons and monocarboxylic acids, H⁺ binds to MCT firstly, then it binds to monocarboxylate anion and transports through the cell membrane in the same direction, and then releases in reverse order. SLC16A7 is often highly expressed during cell carcinogenesis. High expression of SLC16A7 may be associated with the clinical stage of breast cancer, tumor size, axillary lymph node metastasis, and tumor differentiation, and plays an important role in the occurrence and development of breast cancer. MCT2 was also overexpressed in prostate cancer, and selective methylation of MCT2 promoter in cells was repeated.

SLC16A7 Membrane Protein Introduction Fig.1 The relationship between breast cancer cells and fat cells and MCT2 in the microenvironment of breast tissue.

Application of SLC16A7 Membrane Protein in Literature

Mazuel L., et al. A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation. Plos one. 2017, 12(4): e0174990. PubMed ID: 28388627

This article shows that glucose-derived lactate is locally produced following neuronal activation, and its use by neurons via MCT2 is probably essential to maintain synaptic activity within the barrel cortex.
Huang C.H., et al. Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate. Nature communications. 2017, 8: 13706. PubMed ID: 28281525

This article reveals that adipocytes promote malignancy of MCT2-expressing breast cancer via β-hydroxybutyrate potentially by inducing the epigenetic upregulation of tumor-promoting genes.
Hoshino D., et al. Exercise-induced expression of monocarboxylate transporter 2 in the cerebellum and its contribution to motor performance. Neurosci Lett. 2016, 633: 1-6. PubMed ID: 27619538

The authors find that actate transport via MCT2 in the cerebellum may play an important role in motor performance and exercises can increase MCT2 expression at the transcriptional level.
Gomes N.P., et al. Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer. Oncotarget. 2015, 6(25): 21675-21684. PubMed ID: 2603535

Studies in this article have shown that selective demethylation of SLC16A7 / MCT2 promoter occurs in prostate cancer. MCT2 knock-down attenuates the growth of prostate cancer cells and is likely to disrupt the metabolic balance at peroxisomes with implications for the proliferation rates of PCa cells and the activation of oncogenic pathways in PCa linked with the EMT process.
Valenca I., et al. Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer. J Cell Mol Med. 2015, 19(4): 723-733. PubMed ID: 25639644

The authors demonstrate that MCT2 is mainly located in peroxisomes in prostate cancer cells and interacts with Pex19 to utilize peroxidase transporters.

SLC16A7 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC16A7 antibody development services.

Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.

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