SLC22A13 Membrane Protein Introduction

Introduction of SLC22A13

Solute carrier family 22 member 13 (SLC22A13) is a member of solute carrier family, which in humans is encoded by the SLC22A13 gene. It is also known as Organic cation transporter-like 3 (ORCTL-3). SLC22A13 is highly expressed in kidneys and to a weaker extent in brain, heart, and intestine.

Basic Information of SLC22A13
Protein Name	Solute carrier family 22 member 13
Gene Name	SLC22A13
Aliases	Organic cation transporter-like 3 (ORCTL-3)
Organism	Homo sapiens (Human)
UniProt ID	Q9Y226
Transmembrane Times	12
Length (aa)	551
Sequence	MAQFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNLSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSPKSVPSEKETEAKGRTSSPGVAFVSSTYF

Function of SLC22A13 Protein

SLC22A13 is an evolutionarily conserved transport protein of plasma membranes. In humans and mice, it is mainly manifested in the kidneys. This gene encodes a member of the organic cation transport family. It is located in a gene cluster, with another family member, an organic cation transporter such as 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein acts to regulate the urine salt and is a high-affinity nicotinate exchanger in the kidneys and intestines.

Fig.1 The structure of SLC22A13 Protein.

Application of SLC22A13 Protein in Literature

Irshad S., et al. Isolation of ORCTL3 in a Novel Genetic Screen for Tumor-Specific Apoptosis Inducers.Cell death and differentiation. 2009, 16 (6): 890–898. PubMed ID: 19282870.

This article provides evidence that SLC22A13 leads to apoptosis through ER stress-mediated mechanisms. ORCTL3 was detected to be down-regulated in human kidney tumors.
Zhu C., et al. Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs. PLoS ONE. 2015, 10 (11): e0140569. PubMed ID: 26536134.

These findings not only link functionality to evolutionarily conservative topics, but also point to the need for a modified SLC22 classification.
Lozano E., et al. Genetic Heterogeneity of SLC22 Family of Transporters in Drug Disposition. Journal of Personalized Medicine. 2018, 8 (2): 14. PubMed ID: 29659532.

The results suggest that the SLC22 family of transporters has an important influence on physiology, pharmacology and toxicology.
Schulz C., et al. SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct. Biochemical Journal. 2014, 457(2):243. PubMed ID: 24147638.

The authors propose that in type A cells, SLC22A13 compensates for proton withdrawal by expelling the basolateral side of anions and glutamate
Bahn A., et al. Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13). Journal of Biological Chemistry. 2008, 283(24):16332-16341. PubMed ID: 18411268.

The results imply that Uricosurics, diuretics, and cyclosporine A have substantial interactions with hOAT10.

SLC22A13 Preparation Options

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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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