SLC22A14 Membrane Protein Introduction

Introduction of SLC22A14

Solute carrier family 22 member 14 (SLC22A14), which is an organic anion/cation transporter, is a protein encoded by the SLC22A14 gene in humans. SLC22A14 is also known as organic cation transporter-like 4 (ORCTL-4). It is highly similar to organic cation transporters in humans. SLC22A14 is predicted to encode an approximately 70-kDa protein with 12 transmembrane regions. The gene SLC22A14 is widely found in many mammals.

Basic Information of SLC22A14
Protein Name	Solute carrier family 22 member 14
Gene Name	SLC22A14
Aliases	Organic cation transporter-like 4 (ORCTL-4)
Organism	Homo sapiens (Human)
UniProt ID	Q9Y267
Transmembrane Times	12
Length (aa)	594
Sequence	MAGEENFKEELRSQDASRNLNQHEVAGHPHSWSLEMLLRRLRAVHTKQDDKFANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTDTCQDGWIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAILSLTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQIRNKVKDMKTKETSSDDV

Function of SLC22A14 Protein

Solute carrier (SLC) transporters are a large family of proteins involved in the transport of various substances such as ions, amino acids, sugars, metabolites, and foreign organisms (such as drugs). The SLC family consists of more than 350 genes, divided into 52 subfamilies, homologous in function and sequence. The Northern blotting analysis shows that human SLC22A14 expression appears to be ubiquitous, but it is most prominent in the testis. More interestingly, SLC22A14 is a candidate gene that causes male infertility in oligo-mutant mice.

Fig.1 The structure of SLC22A14 Protein.

Application of SLC22A14 Protein in Literature

Huo F.Y., et al. Expressions of SLC22A14 and SPAG6 proteins in the ejaculated sperm of idiopathic asthenozoospermia patients. National Journal of Andrology. 2017, 23 (8):703-707.PubMed ID: 29726644.

The expressions of SLC22A14 and SPAG6 are reduced in the sperm of the patients with idiopathic asthenospermia, which may be one of the important causes of asthenospermia.
Maruyama S., et al. A Critical Role of Solute Carrier 22a14 in Sperm Motility and Male Fertility in Mice. Scientific Reports. 2016, (6): 36468. PubMed ID: 27811987.

These results demonstrated that SLC22A14 plays a pivotal role in normal flagellar structure, motility and fertility in mouse spermatozoa.
Yamada H., et al. Effect of splice-site polymorphisms of the TMPRSS4, NPHP4, and ORCTL4, genes on their mRNA expression. Journal of Genetics. 2005, 84 (2):131-136.PubMed ID: 16131712.

Since the proteins encoded by all these transcripts are associated with relatively significant structural changes in the form of amino acid insertion/deletion and premature termination, their functional ability may be greatly reduced.
Nishiwaki T., et al. Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters. Cytogenetics & Cell Genetics. 1998, 83 (3-4):251-255. PubMed ID: 10072596.

These results suggest that SLC22A14 has approximately 27 kb to ORCTL3 in the genomic DNA sequence, in a tail-to-head direction. And ORCTL4 is clustered in a 52kb region of genomic DNA.
Mihaljevic I., et al. Phylogenetic, Syntenic, and Tissue Expression Analysis of slc22 Genes in Zebrafish (Danio Rerio). BMC Genomics. 2016, (17): 626. PubMed ID: 26848304.

Clear orthological relationships of zebrafish slc22 and other vertebrate slc22 genes were established. Most of the members of slc22 are highly conservative, indicating their physiological and toxicological importance.

SLC22A14 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC22A14 antibody development services.

Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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