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- Anti-SLC44A4-VC-Mc-MMAE ADC
Anti-SLC44A4-VC-Mc-MMAE ADC (CAT#: ADC-W-448)
This ADC product is comprised of an anti-SLC44A4 monoclonal antibody conjugated via a VC-Mc linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Name
- SLC44A4
- Alternative Names
- CTL4; NG22; TPPT; C6orf29
- Target Entrez Gene ID
- 80736
- Target UniProt ID
- Q53GD3
- Overview
- The protein encoded by this gene may be a sodium-dependent transmembrane transport protein involved in the uptake of choline by cholinergic neurons. Defects in this gene can cause sialidosis, a lysosomal storage disease. Three transcript variants encoding different isoforms have been found for this gene.
- Overview
- Human Anti-SLC44A4 Antibody
- Species Reactivity
- Human
- Name
- VC-Mc- (valine-citrulline-maleimidocaproyl)
- Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Name
- MMAE (Monomethyl auristatin E)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
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Other Products
Same Target
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-476 | Anti-SLC44A4 (AGS-5)-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-447 | Anti-SLC44A4 (clone AGS-5)-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-449 | Anti-SLC44A4-Mc-MMAE ADC | Mc (maleimidocaproyl) | MMAE (Monomethyl auristatin E) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-017 | anti-HIgG(Fab)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-011 | anti-HIgG(Fc)Fab-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-W-465 | Anti-TNFRSF8 (Brentuximab)-VC-PAB-MMAE ADC | VC-PAB (valine-citrulline with PAB) | MMAE (Monomethyl auristatin E) |
| ADC-AA-052 | Protein A-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-021 | anti-MIgG(Fc)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
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