ActivatorPep™ MAGE-A1, human-L (CA-LX046)

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Product Name
ActivatorPep™ MAGE-A1, human-L

Cat. No.
CA-LX046

Product Summary
Creative Biolabs provides an extensive cell activation reagents including Expansion Kits and Activator peptides for global custom, which are suitable to many applications, such as in vitro stimulation antigen-specific cells. MAGE-A1 is a pool of lyophilized peptides, consisting mainly of 15-mer sequences with 11 amino acids overlap, covering the complete sequence of the human MAGE-A1 protein (UniProt ID: P43355). Which can be used for in vitro stimulation of MAGE-A1-specific CD4+ and CD8+ T cells.

Background Information
Melanoma-associated antigen 1 (MAGE-A1) belongs to the cancer testis family of antigens, which are highly expressed in male germ cells but generally not in other normal tissues. Aberrant expression of MAGE-A1 is found in variable proportions of different solid and hematological cancer types, e.g., in melanoma and multiple myeloma patients. MAGE-A1 was described to be an attractive antigen to monitor anti-tumor T cell responses and to be used for immunotherapeutic interventions.

Applications
Stimulation Reagents

Cross-reactivity
No significant cross-reactivity was observed among analytes in this panel.

Species Reactivity
Human

Purity or Quality Grade
Research Grade

Downstream Application
Pulsing of antigen-presenting cells for research;
Detection and analysis of antigen-specific CD4+ and CD8+ effector/memory T cells in PBMCs;

Product Size
for stimulation of 1×109 cells

Shipping Condition
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage Conditions
Store at -20°C.

Shelf life
> 6 Months from date of receipt under proper storage condition.

Product Use Statement
For research use only, not for diagnostic or therapeutic use.

Product Features
Efficient expansion and increased survival rate of Ag-specific T cells;
Provides a gentle activation stimulus that maintains high viability of activated and expanded T cells;

Principle of the Assay
MAGE-A1 peptide pools have been developed for the efficient in vitro stimulation of antigen-specific T cells, as peptides of 15 amino acids in length and 11 amino acids overlap represent an optimized solution for stimulating both CD4+ and CD8+ T cells in various applications.

Research Category
Immunology

Panel Type
Stimulation for CD4+ and CD8+ T cells

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.