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Anti-B7-H4 TCR-ABR-α (XW-913) CAR Vector (XS-1122-YF1833)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-B7-H4 TCR-fused Antigen Binding Receptor (TCR-ABR) CAR is constructed for the engineering of T cells to target Human B7-H4. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv (XW-913) of anti-B7-H4 antibody linked to TCRα subunit. The vector product was designed for the discovery and development of cellular therapy against Gastric cancer. The TCR-ABR can effectively reprogram an intact TCR complex to recognize tumor surface antigens. TCR-ABR-T cells are shown to engage the signaling capacity of the entire TCR complex in an HLA-independent manner.

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Details

  • Target
  • B7-H4
  • Targeting Cell Type
  • T Cell
  • Targeting Diseases
  • Gastric cancer
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • scFv-TCRα
  • Discription of Signaling Cassetes
  • The scFv used to generate CAR-T cells or single domain antibodies can be fused to the extracellular N-termini of TCRα, TCRβ, CD3γ, CD3δ, or CD3ε subunits, resulting in the activation of target-specific TCR-ABR-T cells. TCR-ABR-T cells have been shown to use the entire TCR complex's signaling capacity in an HLA-independent manner.

Target

  • Clone
  • XW-913
  • Host
  • Human
  • Target Species
  • Human
  • Gene Name
  • V-set domain containing T cell activation inhibitor 1
  • Synonyms
  • B7-H4, B7H4, B7S1, B7X, B7h.5, PRO1291, VCTN1
  • Introduction
  • This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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