Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsGet a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
EXPLORE MOREAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
B7-H4 also know as V-set domain-containing T-cell activation inhibitor 1(VTCN1), is a protein that in humans is encoded by the VTCN1 gene. B7H4 belongs to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. B7-H4 is a transmembrane protein that binds an unknown receptor on activated T cells resulting in inhibition of T-cell effector function via cell cycle arrest, decreased proliferation, and reduced IL-2 production. B7-H4 is up-regulated on the surface of cancer cells and immunosuppressive tumor-associated macrophages (TAMs) in a variety of human cancers. B7-H4 expression levels inversely correlate with patient survival in ovarian cancer, making B7-H4 an attractive candidate for therapeutic intervention.
Associated Disease
Loading...
| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-LC237 | Anti-B7-H4 (56) h(-CD28-CD3ζ) CAR, pCDCAR1 | Human | 56 | Human | scFv--CD28-CD3ζ | Lentiviral | T cell | ||
| CAR-LC238 | Anti-B7-H4 (26) h(-CD28-CD3ζ) CAR, pCDCAR1 | Human | 26 | Human | scFv--CD28-CD3ζ | Lentiviral | T cell | ||
| CAR-LC239 | Anti-B7-H4 (54) h(-CD28-CD3ζ) CAR, pCDCAR1 | Human | 54 | Human | scFv--CD28-CD3ζ | Lentiviral | T cell | ||
| CAR-LC240 | Anti-B7-H4 (68) h(-CD28-CD3ζ) CAR, pCDCAR1 | Human | 68 | Human | scFv--CD28-CD3ζ | Lentiviral | T cell | ||
| XS-0822-YF913 | Anti-Human B7-H4 (XW-913) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-913 | Human | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1833 | Anti-Human B7-H4 (XW-913) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-913 | Human | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2753 | Anti-Human B7-H4 (XW-913) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-913 | Human | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0922-ZP1071 | Anti-B7-H4 (3#68) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 3#68 | Human | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-0922-ZP1381 | Anti-B7-H4 (3#68) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | 3#68 | Human | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-1122-YF1833 | Anti-B7-H4 TCR-ABR (scFv-TCRα, XW-913) CAR Plasmid, pCDCAR1 | Human | XW-913 | Human | scFv-TCRα | Lentiviral vector | T Cell | ||
| XS-1122-YF2753 | Anti-B7-H4 TCR-ABR (scFv-TCRβ, XW-913) CAR Plasmid, pCDCAR1 | Human | XW-913 | Human | scFv-TCRβ | Lentiviral vector | T Cell | ||
| XS-1122-YF3673 | Anti-B7-H4 TCR-ABR (scFv-CD3γ, XW-913) CAR Plasmid, pCDCAR1 | Human | XW-913 | Human | scFv-CD3γ | Lentiviral vector | T Cell | ||
| XS-1122-YF4593 | Anti-B7-H4 TCR-ABR (scFv-CD3δ, XW-913) CAR Plasmid, pCDCAR1 | Human | XW-913 | Human | scFv-CD3δ | Lentiviral vector | T Cell | ||
| XS-1122-YF5513 | Anti-B7-H4 TCR-ABR (scFv-CD3ε, XW-913) CAR Plasmid, pCDCAR1 | Human | XW-913 | Human | scFv-CD3ε | Lentiviral vector | T Cell | ||
| XS-1122-YF6433 | Anti-B7-H4 (XW-913) h(CD28-CD3ζ) CAR, pAAV | Human | XW-913 | Human | scFv-CD28-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-1122-YF7353 | Anti-B7-H4 (XW-913) h(41BB-CD3ζ) CAR, pAAV | Human | XW-913 | Human | scFv-41BB-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-1122-YF8273 | Anti-B7-H4 (XW-913) h(CD28-41BB-CD3ζ) CAR, pAAV | Human | XW-913 | Human | scFv-CD28-41BB-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-0123-ZP784 | Anti-B7-H4 (3#68) h(scFv-CD3ε) TRuC, pCDTRC1 | Human | 3#68 | Human | scFv-CD3ε | Lentiviral vector | T cell | ||
| XS-0323-ZP784 | Anti-B7-H4 (3#68 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 | Human | 3#68 | Human | scFv-CD28TM-CD79β | Lentiviral vector | T cell | CAR-B Vector | |
| XS-0923-LX107 | Anti-hB7-H4 (CD28-41BB-CD3ζ) CAR-duplex CTLA4 pCDCAR1 Vector | Human | X9X-76 | scFv-CD28-41BB-CD3ζ-duplex CTLA4 | Lentiviral vector | T cell | CAR-T |
NEWSLETTER
The latest newsletter to introduce the latest breaking information, our site updates, field and other scientific news, important events, and insights from industry leaders
LEARN MORE NEWSLETTER
NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
LEARN MORE SOLUTION
NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
LEARN MORE NOVEL TECHNOLOGY
NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
LEARN MORE SOLUTION
