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The vector of anti-B7-H4 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human B7-H4. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-B7-H4 antibody linked to 4-1BB and CD3ζ signaling domains. And the vector product was designed for the treatment of Ovarian cancer.
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CAR Construction :
Fig.1 Flow cytometric analysis of either B7-H4 WT/293 or B7-H4 H250Q MT/293 transfectants showed that the stable transfected cell lines were successfully constructed. Shown are mean ± SD values from three independent triplicates. Zhang, L., Wu, H., Lu, D., Li, G., Sun, C., Song, H., ... & Zhang, X. (2013). The costimulatory molecule B7-H4 promote tumor progression and cell proliferation through translocating into nucleus. Oncogene, 32(46), 5347-5358. |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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