Anti-CD38 AbTCR, pCDTCR1 (AbT-ZP001)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The AbTCR fuses an antigen-binding domain from anti-CD38 (38SB39) antibody with the C- terminal signaling domain of a γδTCR. More specifically, the antigen-binding domain of our AbTCR is an antibody Fab fragment, and the cellular-activation domain of consists of portions of the δ and γ chains of a γδTCR. And the vector product is designed to facilitate T-cell cytotoxicity with low cytokine release and is used in Multiple Myeloma.

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Details

Target
CD38

Targeting Cell Type
T cell

Targeting Diseases
Multiple Myeloma

Vector Name
pCDTCR1

Vector length
~8kb

Vector Type
Lentiviral vector

Receptor Construction
Fab-γδ TCR

Discription of Signaling Cassetes
Fab-γδ TCR
In the majority of T cells, the TCR consists of an α chain and a β chain, whereas in 1–5% of T cells the TCR consists of a gamma (γ) and a delta (δ) chain. However, there were technical hurdles with the mispairing with the T-cell's endogenous α and β TCR chains and having to express two synthetic molecules in the same cell. Instead of previous designs that were built on αβ chains of the TCR, our AbTCR platform avoids mispairing with the T cell's endogenous αβTCR by using the transmembrane and intracellular domains from the γδTCR. Similar to the exogenously-expressed TCR in TCR-T cells, our AbTCR engages the endogenous CD3 complex to initiate T-cell activation. However, since the γδTCR chains do not bind with the TCRs in αβ T-cells, AbTCR avoids the mispairing challenge of traditional αβTCR-based synthetic receptors.
In addition, by employing a Fab as the antigen-binding domain, the AbTCR can be used to target either peptide-MHC complexes or cell surface antigens by using TCR-mimic or conventional antibodies respectively.
Overall, the AbTCR design couples the antigen-binding utility of an antibody to the endogenous TCR activation pathways.

Target

Clone
38SB39

Host
Human

Target Species
Human

Gene Name
CD38

Gene ID
952

Synonyms
CD38;CD38; CD38 Molecule; CD38 Molecule; ADP-Ribosyl Cyclase 1; 2-Phospho-Cyclic-ADP-Ribose Transferase; Cyclic ADP-Ribose Hydrolase 1; 2-Phospho-ADP-Ribosyl Cyclase; NAD(+) Nucleosidase; CD38 Antigen (P45); ADPRC 1; 2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase; Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase;

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-CD38 AbTCR, pCDTCR1 (AbT-ZP001)

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