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The vector of anti-CEACAM5 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human CEACAM5. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CEACAM5 antibody linked to 41BB and CD3ζ signaling domains. And the vector product was designed for the treatment of Colorectal cancer.
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CAR Construction :
Fig.1 Phenotypic analysis of NK cells. NK cells were analyzed by flow cytometry for the expression of NK markers and CEACAM5. Data are presented as percentage of viable cells expressing the cell surface proteins. Fantini, M., David, J. M., Annunziata, C. M., Morelli, M. P., Arlen, P. M., & Tsang, K. Y. (2020). The monoclonal antibody NEO-201 enhances natural killer cell cytotoxicity against tumor cells through blockade of the inhibitory CEACAM5/CEACAM1 immune checkpoint pathway. Cancer Biotherapy & Radiopharmaceuticals, 35(3), 190-198. |
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CAR Construction :
Fig.2 Blocking with NEO-201 enhances NK killing and is directly correlated with the level of CEACAM5+/NEO201+ cells. Figure represents additional flow cytometry analysis and non-ADCC NK cell cytotoxicity assays performed on human lung carcinoma cell line HCC827. Fantini, M., David, J. M., Annunziata, C. M., Morelli, M. P., Arlen, P. M., & Tsang, K. Y. (2020). The monoclonal antibody NEO-201 enhances natural killer cell cytotoxicity against tumor cells through blockade of the inhibitory CEACAM5/CEACAM1 immune checkpoint pathway. Cancer Biotherapy & Radiopharmaceuticals, 35(3), 190-198. |
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