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The vector of anti-CEACAM5 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human CEACAM5. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CEACAM5 antibody linked to 41BB and CD3ζ signaling domains. And the vector product was designed for the treatment of Colorectal cancer.
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CAR Construction :
Fig.1 Bladder cancer cells T2-4 were transfected with CEACAM5 expression plasmids and subjected to flow cytometry analysis with CC4. Characterization of mAb CC4 and identification of mAb CC4 antigen. Zheng, C., Feng, J., Lu, D., Wang, P., Xing, S., Coll, J. L., ... & Yan, X. (2011). A novel anti-CEACAM5 monoclonal antibody, CC4, suppresses colorectal tumor growth and enhances NK cells-mediated tumor immunity. PloS one, 6(6), e21146. |
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CAR Construction :
Fig.2 mAb CC4 suppressed proliferation, migration and aggregation of colorectal cancer cells. Statistically significant differences between mAb CC4 treated groups and control groups were indicated by double stars (**P<0.01). Zheng, C., Feng, J., Lu, D., Wang, P., Xing, S., Coll, J. L., ... & Yan, X. (2011). A novel anti-CEACAM5 monoclonal antibody, CC4, suppresses colorectal tumor growth and enhances NK cells-mediated tumor immunity. PloS one, 6(6), e21146. |
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CAR Construction :
Fig.3 mAb CC4 blocked the suppression of NK killings induced by over-expression of CEACAM5 in colorectal cancer cells. Forced expressions of CEACAM1 and CEACAM5 in HCT-15 cells were confirmed by flow cytometry. Zheng, C., Feng, J., Lu, D., Wang, P., Xing, S., Coll, J. L., ... & Yan, X. (2011). A novel anti-CEACAM5 monoclonal antibody, CC4, suppresses colorectal tumor growth and enhances NK cells-mediated tumor immunity. PloS one, 6(6), e21146. |
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