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The vector of anti-EGFR chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human EGFR. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-EGFR antibody linked to 4-1BB(CD137), OX40 and CD3ζ signaling domains. And the vector product was designed for the treatment of multiple myeloma.
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CAR Construction :
Fig.1 FACS analysis on PTC cell lines stained with anti-EGFR Ab (dark black peak), with a mouse IgG1 isotype control (grey dotted peak) or only with the secondary labelled Ab (black peak). One representative experiment of two is shown. Degl'Innocenti, D., Alberti, C., Castellano, G., Greco, A., Miranda, C., Pierotti, M. A., ... & Tomassetti, A. (2010). Integrated ligand-receptor bioinformatic and in vitro functional analysis identifies active TGFA/EGFR signaling loop in papillary thyroid carcinomas. PLoS One, 5(9), e12701. |
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CAR Construction :
Fig.2 TGFA production by thyroid cell lines. Media without FBS were conditioned for 48 h by confluent cells and analyzed by ELISA. Degl'Innocenti, D., Alberti, C., Castellano, G., Greco, A., Miranda, C., Pierotti, M. A., ... & Tomassetti, A. (2010). Integrated ligand-receptor bioinformatic and in vitro functional analysis identifies active TGFA/EGFR signaling loop in papillary thyroid carcinomas. PLoS One, 5(9), e12701. |
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CAR Construction :
Fig.3 FBP expression on IGROV1 cells and their cisplatin-resistant variants IGROV1/Pt 0.5 and IGROV1/Pt. All measurements were performed in triplicate. Ottone, F., Miotti, S., Bottini, C., Bagnoli, M., Perego, P., Colnaghi, M. I., & Ménard, S. (1997). Relationship between folate-binding protein expression and cisplatin sensitivity in ovarian carcinoma cell lines. British Journal of Cancer, 76(1), 77-82. |
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