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EGFR

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases (RTK). These trans-membrane proteins are activated following binding with peptide growth factors of the EGF-family of proteins. Evidence suggests that the EGFR is involved in the pathogenesis and progression of different carcinoma types. The EGFR and EGF-like peptides are often over-expressed in human carcinomas. Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including squamous-cell carcinoma of the lung (80% of cases), anal cancers, glioblastoma (50%) and epithelian tumors of the head and neck (80-100%).

EGFR Associated Disease
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-ZP8476 A uniCAR [Anti-FITC CAR], with a mAb-based CAR Adaptor [Anti-EGFR (Cetuximab)], a Switchable CAR System Breast cancer Lentiviral vector   Add to Cart   Datasheet
CAR-ZP8493 A uniCAR [Anti-CD16 CAR], with a mAb-based CAR Adaptor [Anti-EGFR (Cetuximab)], a Switchable CAR System Breast cancer Lentiviral vector   Add to Cart   Datasheet
CAR-ZP8494 A uniCAR [Anti-CD16 CAR], with a mAb-based CAR Adaptor [Anti-EGFR (Panitumumab)], a Switchable CAR System Breast cancer Lentiviral vector   Add to Cart   Datasheet
XS-0922-ZP1295 Anti-EGFR (mAb806) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human mAb806 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-0922-ZP1296 Anti-EGFR (C225) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human C225 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1122-YF1235 Anti-EGFR TCR-ABR (scFv-TCRα, XW-315) CAR Plasmid, pCDCAR1 Human XW-315 Mouse scFv-TCRα Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF1236 Anti-EGFR TCR-ABR (scFv-TCRα, XW-316) CAR Plasmid, pCDCAR1 Human XW-316 Mouse scFv-TCRα Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF1237 Anti-EGFR TCR-ABR (scFv-TCRα, Cetuximab) CAR Plasmid, pCDCAR1 Human Cetuximab Mouse scFv-TCRα Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF1238 Anti-EGFR TCR-ABR (scFv-TCRα, XW-318) CAR Plasmid, pCDCAR1 Human XW-318 Mouse scFv-TCRα Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF1239 Anti-EGFR TCR-ABR (scFv-TCRα, XW-319) CAR Plasmid, pCDCAR1 Human XW-319 Human scFv-TCRα Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF1240 Anti-EGFR TCR-ABR (scFv-TCRα, XW-320) CAR Plasmid, pCDCAR1 Human XW-320 Mouse scFv-TCRα Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF1241 Anti-EGFR TCR-ABR (scFv-TCRα, XW-321) CAR Plasmid, pCDCAR1 Human XW-321 Mouse scFv-TCRα Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF1242 Anti-EGFR TCR-ABR (scFv-TCRα, XW-322) CAR Plasmid, pCDCAR1 Mouse XW-322 Rabbit scFv-TCRα Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF1243 Anti-EGFR TCR-ABR (scFv-TCRα, XW-323) CAR Plasmid, pCDCAR1 Mouse XW-323 Mouse scFv-TCRα Lentiviral vector T Cell   Add to Cart   Datasheet
XS-0123-ZP504 Anti-EGFR (7A7) h(scFv-CD3ε) TRuC, pCDTRC1 Mouse 7A7 Mouse scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP505 Anti-EGFR (D1D4J) h(scFv-CD3ε) TRuC, pCDTRC1 Mouse D1D4J Rabbit scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0323-LX380 Anti-EGFR VHH(X3XH11) h(ICOS-41BB-CD3ζ) CAR, pCDCAR1 Vector Human X3XH11 VHH-ICOS-4-1BB-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX381 Anti-EGFR VHH(X3XH12) h(ICOS-41BB-CD3ζ) CAR, pCDCAR1 Vector Human X3XH12 VHH-ICOS-4-1BB-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX382 Anti-EGFR VHH(X3XH13) h(ICOS-41BB-CD3ζ) CAR, pCDCAR1 Vector Human X3XH13 VHH-ICOS-4-1BB-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX3835 TRAC-EGFR (X3XT37) h(CD28-41BB-CD3ζ) replaced CAR, pcDNA Vector Human X3XT37 Human Homology arm-EF1a-scFv-CD28-41BB-CD3ζ-Homology arm Nonviral T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX4077 TRAC-EGFR (X3XT37) h(CD28-OX40-CD3ζ) replaced CAR, pcDNA Vector Human X3XT37 Human Homology arm-EF1a-scFv-CD28-OX40-CD3ζ-Homology arm Nonviral T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX4319 TRAC-EGFR (X3XT37) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector Human X3XT37 Human Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm Nonviral T cell CAR-T   Add to Cart   Datasheet
XS-0923-LX62 Anti-hEGFR (CD28-41BB-CD3ζ) CAR-duplex CTLA4 pCDCAR1 Vector Human X9X-31 scFv-CD28-41BB-CD3ζ-duplex CTLA4 Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
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