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The vector of anti-EGFR chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human EGFR. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-EGFR antibody linked to 41BB and CD3ζ signaling domains. And the vector product was designed for the treatment of NSCLC.
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CAR Construction :
Fig.1 Antitumor capabilities of EGFR antibodies in EGFRvIII and wtEGFR-expressing gliomasphere lines. Representative plots for the in vitro inhibition of proliferation in gliomaspheres expressing EGFRvIII after 7 days of treatment with 10 µg/mL of singular antibodies or domain III-targeting antibodies in combination with ch806 measured by Vialight assay Jin, K. T., Chen, B., Liu, Y. Y., Lan, H., & Yan, J. P. (2021). Monoclonal antibodies and chimeric antigen receptor (CAR) T cells in the treatment of colorectal cancer. Cancer Cell International, 21(1), 1-15. |
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CAR Construction :
Fig.2 EGFR expression on different human tumor cell lines. Analysis of cell surface EGFR expression level was performed by flow cytometry. Albert, S., Arndt, C., Koristka, S., Berndt, N., Bergmann, R., Feldmann, A., ... & Bachmann, M. (2018). From mono-to bivalent: improving theranostic properties of target modules for redirection of UniCAR T cells against EGFR-expressing tumor cells in vitro and in vivo. Oncotarget, 9(39), 25597. |
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CAR Construction :
Fig.3 Comparison of the affinities of the mono- and bivalent EGFR-specific TMs. For estimation of the respective Kd value increasing amounts of monovalent α-EGFR TM (triangle) or bivalent α-EGFR-EGFR TM (rectangle). Albert, S., Arndt, C., Koristka, S., Berndt, N., Bergmann, R., Feldmann, A., ... & Bachmann, M. (2018). From mono-to bivalent: improving theranostic properties of target modules for redirection of UniCAR T cells against EGFR-expressing tumor cells in vitro and in vivo. Oncotarget, 9(39), 25597. |
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