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Anti-MSLN h(28ζ) CART, Combined with R59949 (CARP-LX-041)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Anti-MSLN h(28ζ) CART, Combined with R59949 represents a CAR Plus system, which can be used in the research of Hematological malignancies. In the system, the transduced CAR lentiviral vector was constructed to express scFv of an anti-MSLN antibody linked to the CD28-CD3ζ signaling domains.The CAR Plus system combined R59949 to improve the antitumor activity and reduce CRS in adoptive immunotherapy. Creative Biolabs provides customized CAR Plus system design and construction services. Please contact us for more detailed information.

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Details

  • Target
  • MSLN
  • Targeting Diseases
  • Hematological malignancies
  • Generation
  • Second
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • CD28-CD3ζ
  • Discription of Signaling Cassetes
  • CD28
    CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide costimulatory signals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells (APC). CD28 modulates the primary TCR/CD3ζ signal in a different fashion than the late costimulatory elements OX40 and CD28. CD28 enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. CAR+ T cells containing the CD28 endodomain showed strikingly enhanced sustained T cell activation, growth, survival. And CD28 results in a brightly expressed, stable receptor as the transmembrane domain. Including CD28 costimulatory domains in CARs led to enhanced anti-malignancy efficacy.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.

Target

  • Target Species
  • Human
  • Gene Name
  • mesothelin
  • Synonyms
  • Mesothelin;MSLN; mesothelin; MPF; SMRP;

Small Molecular Details

  • Small melocular
  • R59949
  • Small molecular Background
  • R59949 is a DGK inhibitor. It also strongly inhibits the activity of type I DGK α and γ. Moreover, it moderately attenuates the activity of type II DGK θ and κ. Moreover, R59949 activates protein kinase C (PKC) by enhancing the levels of the endogenous ligand diacylglycerol.
  • PubChem CID
  • 657356
  • Combined molecular Synonyms
  • Diacylglycerol Kinase Inhibitor Ii; 120166-69-0; R59949; R 59949; R-59949; R 59 949; MLS000069510; SMR000058550;
  • Molecular Weight
  • 489.6g/mol

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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