Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
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EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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EXPLORE MOREAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
The anti-MUC16 TriCAR is a novel chimeric antigen receptor (CAR) constructed for the engineering of T cells to target Human MUC16.More specifically, the TriCAR is a CAR-T with unique TriTE (Tri-functional T cell Engager) construct. In general, TriTE is a fusion protein with unique functions including T cell engagement, T cell stimulation, and check point blocking. It consists of five components, including R1(antigen binding domain), R2 (anti-CD3, here refer to the CD28/4-1BB-CD3ζ intracellular constimulatory domain), R3 & R4(IL15 binding domain), and R5 (PD1 for binding to PD-L1). Therefore, the TriCAR contains an anti-antigen scFv, a PD-L1 blocker, and a cytokine complex, enabling the TriCAR/SILK to simultaneously targeting the antigen-specific cancer cells, blocking the inhibitory PD-L1 signal and stimulating innate T/NK cell activation and expansion, thus make it a tri-functional CAR (Tri-CAR).
There are currently no customer reviews or questions for Anti-MUC16 TriCAR (DS6v1.01) (scFv-Sushi Domain-4-1BB-CD3ζ-PP2A-IL15-Anti-PD-L1), pCDCAR1 (TriCAR-Z422). Click the button below to contact us or submit your feedback about this product.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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