Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Creative Biolabs is a leading provider of mouse models for biomedical research and preclinical drug discovery. We know that selecting the appropriate animal model is extremely critical to your research studies. Creative Biolabs is committed to providing you with high-quality donor-dependent in vivo mouse model to support your cytokine release syndrome (CRS) research. From genetically standard and disease-specific models to surgically altered animals, you can trust us to be an integral part of your research programs.
Although immuno-oncology therapies such as bispecific antibodies, checkpoint inhibitors, and CAR-T cells have been successfully used as cancer therapy, they can have severe adverse effects such as CRS. The animal models and in vitro human PBMC assays presently in use can't reliably predict CRS in patients. A predictive assay that can screen for patient/cancer/therapy combinations at risk for developing CRS would improve the safety of immuno-oncology drug development. Currently, many donor-dependent in vivo models for single agent or drug combination cytokine release syndrome safety evaluation have been reported.
Creative Biolabs has developed a series of novel, sensitive, rapid, and reproducible in vivo PBMC humanized mouse models. These models are able to differentiate human PBMC donors based on individual cytokine release response. Based on this model, researchers could evaluate cytokine release in response to drug candidate. Besides, our mouse model uses luciferase labelled cell lines to allow the measurement of tumor burden at the time of treatment as well as assess short term tumor response. This mouse model will have immediate utility in current and future personalized precision medicine.
Creative Biolabs also offer a repository of off-shelf in vivo mouse models that can be directly used for CRS studies. As an experienced CRO company, Creative Biolabs is able to offer you:
Please contact us for more information about our donor-dependent in vivo mouse model products or services.
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