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The vector of anti-EGFRvIII chimeric antigen receptor (CAR) is constructed for the engineering of NK cells to target human EGFRvIII. The NK cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-EGFRvIII antibody linked to DAP12 signaling domains. And the vector product was designed for the treatment of Glioblastoma.
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CAR Construction :
Fig.1 Affinity determination of RAbDMvIII by Saturation ELISA. The concentration range for RAbDMvIII and RAbvIII was 20 to 0.02 ug/ml (x axis) and the absorbance was read at 450 nm (Y axis). Gupta, P., Han, S. Y., Holgado-Madruga, M., Mitra, S. S., Li, G., Nitta, R. T., & Wong, A. J. (2010). Development of an EGFRvIII specific recombinant antibody. BMC biotechnology, 10(1), 1-13. |
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CAR Construction :
Fig.2 Specificity of RAbDMvII1 by Flow cytometry. Flow cytometric analysis of surface expressed EGFRvIII. Gupta, P., Han, S. Y., Holgado-Madruga, M., Mitra, S. S., Li, G., Nitta, R. T., & Wong, A. J. (2010). Development of an EGFRvIII specific recombinant antibody. BMC biotechnology, 10(1), 1-13. |
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