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Flag tag-m(ζ) Control pCDCAR1 (XS-0522-LX43)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Creative biolabs has developed Lentiviral control CAR vector Flag tag-m(ζ) Control pCDCAR1, which has a flag tag and is constructed for the engineering of T cells as a control system. The T cells are genetically modified through transduction with a Lentiviral control vector linked to CD3-zeta signaling domains.

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Details

  • Target
  • Control
  • Targeting Cell Type
  • T cell
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • Flag tag-m(CD3ζ)
  • Discription of Signaling Cassetes
  • CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ, ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric ICOS and 4-1BB can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.

Target

  • Target Species
  • Mouse
  • Gene Name
  • Control CAR VP
  • Synonyms
  • Control; Control CAR VP

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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