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h(CD3ζ, IL15) Control CAR-Jurkat (XS-0523-LX19)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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Specifications

  • Species
  • Human
  • Host Cell Type
  • T lymphocyte
  • Overexpressed Gene
  • NFAT-Luciferase Reporter-CD28
  • Size
  • 2 million cells per vial
  • Culture Condition
  • Suspension
  • Growth Pattern
  • Exponential growth phase
  • Formulation
  • Frozen cells
  • Cell Purity
  • >90%
  • Cell Viability
  • >80%
  • Mycoplasma Testing
  • Negative
  • Shipping
  • Dry ice
  • Storage
  • Frozen cells should be stored in a liquid nitrogen tank.
  • Warnings
  • Avoid multiple freeze/thaw cycles
  • Quality Control
  • Cultures are screened for the presence of bacteries, yeast, fungi and mycoplasma (DNA amplification). Growth media are also certified based on U.S. Public Health Service Guidelines.
  • Application
  • Proof of concept studies for CAR-T research.

CAR Design

  • Target
  • Control
  • Target Species
  • Human
  • CAR Construction
  • h(CD3ζ)-2A-IL15
  • CAR Signaling Cassetes
  • CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ, ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric ICOS and 4-1BB can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
  • CAR Vector Name
  • pCDCAR1
  • CAR Vector length
  • ~8kb
  • CAR Vector Type
  • Lentiviral vector
  • CAR Generation
  • Second

Customize Your CAR Products

Cannot find the desired product? Don't worry, just try our online CAR and CAR cell customizing system, which offers full options to meet all unique needs, including but not limited to conventional or unconventional CAR constructs, as well as a variety of vectors and cells. The customization process can be completed with just a few simple clicks, please feel free to try it out.
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Customer Reviews and Q&As

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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