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The vector of anti-EGFR chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human EGFR. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-EGFR antibody linked to CD3ζ signaling domains. And the vector product was designed for the treatment of NSCLC.
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CAR Construction :
Fig.1 Flow cytometric analysis of imgatuzumab and cetuximab binding alone or in combination in H322. Effect of anti-EGFR monoclonal antibody treatment on EGFR surface expression levels. Kol, A., van Scheltinga, A. T., Pool, M., Gerdes, C., de Vries, E., & de Jong, S. (2017). ADCC responses and blocking of EGFR-mediated signaling and cell growth by combining the anti-EGFR antibodies imgatuzumab and cetuximab in NSCLC cells. Oncotarget, 8(28), 45432. |
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CAR Construction :
Fig.2 Influence of monoclonal antibody binding on EGFR internalization and surface expression. SW-1573 were surface labeled with the anti-EGFR monoclonal antibodies on ice and incubated at 37 °C for the indicated times, and Kol, A., van Scheltinga, A. T., Pool, M., Gerdes, C., de Vries, E., & de Jong, S. (2017). ADCC responses and blocking of EGFR-mediated signaling and cell growth by combining the anti-EGFR antibodies imgatuzumab and cetuximab in NSCLC cells. Oncotarget, 8(28), 45432. |
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